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MACS Flex-Air



How Air Flows Through the Cage

As HEPA filtered air enters the cage at the back, it must follow a “Mini Barrier” that captures any dust and contaminants that could get by the HEPA to prevent the dust particles from reaching the cage interior. Air is directed downward into the cage via multiple air openings or ports. This creates a laminar flow of air down the cage wall and more efficiently across the cage bedding. The warm gases and moisture are pushed up the opposite cage wall and out the multiple exhaust ports at the top. The air travels through another “Mini Barrier” that captures any animal dander and keeps it from entering the exhaust plenums.










This illustration shows the path of incoming fresh air (blue) along the Mini Barrier and into the cage. Exhaust air (red) coming up the other side and along it’s Barrier path to exit.





The Flex-Air cage provides an extra level of protection to the animals because the supply air does not go directly into the cage. It first follows a “Mini Barrier” to futher trap any dust carrying bacteria. It functions very similar to a Petri Dish.


Air-Block Integral Seal

  • Seal is completely integral to lid. There are no additional parts, so you do not have to remove to clean or autoclave.
  • Seal combines with specially designed wire bar lid and cage edge to help prevent air from escaping or entering cage.
  • Seal material tested to withstand over 200 autoclave cycles.


The Integral Seal’s concave shape fits snuggly over the Flex-Air cage’s molded convex edge to form a secure fit with virtually no air leaks.

Under Negative Containment Pressure
With the MACS rack operating under negative pressure, the Integral Seal is pushed down farther onto the cage’s concex edge due to greater room air pressure. than inside cage pressure. This assures no in-cage contaminants can escape the cage.




Better People Protection – Positive and Negative Pressures
The cage’s Air-Block Integral Seal helps keep animal allergens and particulates from escaping into the macro-environment and away from the people who continually work within that environment. The cage air is directed back through the Mini Barrier to trap dander and particulates. The air then travels into the exhaust plenums and through the HEPA filters to supply clean air back into the room. Or it can exhaust directly out of the building through HVAC. Under negative pressure, Flex-Air is even more effective at protecting people. The static pressure differential is greater in the macro-environment. This outside pressure forces the Integral Seal down on the cage to prevent any leakage from the contaminated cage into the room.

Better Animal Protection – Positive Isolation
Under positive pressure, the static pressure within the cage is higher than the room thereby keeping room contaminates from entering the micro-environment. In addition, the cage’s Mini Barrier traps any dust particles that may carry bacteria should any get by the system’s pre and HEPA filters.



All Around Better Protection
Flex-Air’s cage design with its “Mini Barrier” and Integral Seal provide a more controlled flow of air within the cage. There is virtually no leakage between micro and macro environments for a better barrier. Independent study has shown at least 98% containment.


Independent Testing Proves Flex-Air’s Superior Protection 

Flex-Air Protects Against Cage Contamination
In an independent study Flex-Air severely inhibited bacterial contamination of individual cages while functioning in a highly contaminated macro-environment. Flex-Air also protected the cage micro-environment while disconnected from the rack system in a highly contaminated macro-environment. In addition, cage and individual docking ports were manually coFlexAir8ntaminated with Bacillus subtilis to challenge the “Mini Barrier.” Test confirmed no contamination was tranmitted to the cage interior.


 Flex-Air Protects Against Cage Cross Contamination
Will a contaminated cage spread to surrounding cages within the Flex-Air system? To answer this question a study was developed by an independent research facility. The particulate selected for this test was rice starch. The goals were to measure this particulate in adjacent cages following repetitive docking/undocking of both the contaminated cage and target cages (backflow contamination). Another goal was to measure the particulate in cages following long term exposure to contaminated exhaust. 

FlexAir9A. Contaminated Source Cage
       Tested positive for rice starch
B. Adjacent Cage
       Tested negative for rice starch






No starch particulate contamination could be demonstrated within any of the adjacent cage units regardless of the position, length or type of exposure relative to the point source contamination.


Tests Showed No Contaminants Were Transferred Into Cage Living Space
A summary of the study showed that the rice starch was airborne and entered the airflow system.
More importantly, there was No Particulate Contamination:
• In back flow exposed cages
• In cross contamination cages
• In long term exposure cages.

In short, Flex-Air successfully prevented the spread of an airborne particulate.

Flex-Air operates efficiently at only
30 ACH
to conserve energy resources.

Low ACH meets TIZ-BIFO guideline of <0.2 m/sec at animal level.
Air still flows….even under static conditions. And still with the protection of the Mini Barrier.
No other ventilated mouse cage operates and performs like Flex-Air.